Structural and haemostatic features of pharmaceutical heparins from different animal sources: challenges to define thresholds separating distinct drugs

@inproceedings{Tovar2016StructuralAH,
  title={Structural and haemostatic features of pharmaceutical heparins from different animal sources: challenges to define thresholds separating distinct drugs},
  author={Ana Maria Freire Tovar and Gustavo Requena Santos and Nina V M Capill{\'e} and Adriana A. Piquet and Bianca F. Glauser and Mariana S{\'a} Pereira and Eduardo Vilanova and Paulo A. S. Mour{\~a}o},
  booktitle={Scientific reports},
  year={2016}
}
Heparins extracted from different animal sources have been conventionally considered effective anticoagulant and antithrombotic agents despite of their pharmacological dissimilarities. We performed herein a systematic analysis on the physicochemical properties, disaccharide composition, in vitro anticoagulant potency and in vivo antithrombotic and bleeding effects of several batches of pharmaceutical grade heparins obtained from porcine intestine, bovine intestine and bovine lung. Each of these… CONTINUE READING
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