Structural and functional study of the phenicol-specific efflux pump FloR belonging to the major facilitator superfamily.

@article{Braibant2005StructuralAF,
  title={Structural and functional study of the phenicol-specific efflux pump FloR belonging to the major facilitator superfamily.},
  author={Martine Braibant and Jacqueline Chevalier and Elisabeth Chaslus-Dancla and Jean-Marie Pag{\'e}s and Axel 7 Cloeckaert},
  journal={Antimicrobial agents and chemotherapy},
  year={2005},
  volume={49 7},
  pages={2965-71}
}
The florfenicol-chloramphenicol resistance gene floR from Salmonella enterica was previously identified and postulated to belong to the major facilitator (MF) superfamily of drug exporters. Here, we confirmed a computer-predicted transmembrane topological model of FloR, using the phoA gene fusion method, and classified this protein in the DHA12 family (containing 12 transmembrane domains) of MF efflux transporters. We also showed that FloR is a transporter specific for structurally associated… CONTINUE READING

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