Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection

@article{Patarca1989StructuralAF,
  title={Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection},
  author={R. Patarca and G J Freeman and Ram Pyare Singh and Frank Y Wei and Tim Durfee and Frederick R. Blattner and Daniel R{\'e}gnier and Christine A. Kozak and Beverly A Mock and Herbert C. Morse and Thomas R. Jerrells and Harvey Cantor},
  journal={The Journal of Experimental Medicine},
  year={1989},
  volume={170},
  pages={145 - 161}
}
We describe a murine cDNA, designated Early T lymphocyte activation 1 (ETA-1) which is abundantly expressed after activation of T cells. Eta-1 encodes a highly acidic secreted product having structural features of proteins that bind to cellular adhesion receptors. The Eta-1 gene maps to a locus on murine chromosome 5 termed Ric that confers resistance to infection by Rickettsia tsutsugamushi (RT), an obligate intracellular bacterium that is the etiological agent for human scrub typhus. With one… CONTINUE READING