Structural and functional studies of the HIV-1 pre-integration complex


Background To replicate their genome retroviruses need two key enzymes, the viral reverse transcriptase (RT) and integrase (IN). Soon after viral infection of a target cell, the genomic RNA is reverse transcribed by RT to generate the double-stranded viral DNA that interacts with viral and cellular proteins to form the pre-integration complex (PIC). IN is a… (More)
DOI: 10.1186/1742-4690-10-S1-P76