Structural and functional roles of deamidation of N146 and/or truncation of NH2- or COOH-termini in human αB-crystallin

@inproceedings{Asomugha2011StructuralAF,
  title={Structural and functional roles of deamidation of N146 and/or truncation of NH2- or COOH-termini in human αB-crystallin},
  author={C. O. Asomugha and Ratna Gupta and Om P. Srivastava},
  booktitle={Molecular vision},
  year={2011}
}
PURPOSE The purpose of the study was to determine the relative effects of deamidation and/or truncation on the structural and functional properties of αB-crystallin. METHODS Using wild-type (WT) αB-crystallin and the αB deamidated mutant (i.e., αB N146D), we generated NH(2)-terminal domain deleted (residues no. 1-66; αB-NT), deamidated plus NH(2)-terminal domain deleted (αB N146D-NT), COOH-terminal extension deleted (residues no. 151-175; αB-CT), and deamidated plus COOH-terminal extension… CONTINUE READING
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