Structural and functional recovery from early monocular deprivation in adult rats.

  title={Structural and functional recovery from early monocular deprivation in adult rats.},
  author={Tommaso Pizzorusso and Paolo Medini and Silvia Landi and Sara Baldini and Nicoletta Berardi and Lamberto Maffei},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 22},
Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix with chondroitinase ABC promotes plasticity in the adult visual cortex. We tested whether chondroitinase ABC treatment of adult rats facilitates anatomical, functional, and behavioral recovery from the effects of a period of monocular deprivation initiated during the critical period for monocular… CONTINUE READING
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