Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.

@article{Scherrer1990StructuralAF,
  title={Structural and functional reconstitution of the glucocorticoid receptor-hsp90 complex.},
  author={L C Scherrer and Freidrich C. Dalman and Enrique Massa and S Meshinchi and William A B Pratt},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 35},
  pages={21397-400}
}
Untransformed steroid receptors in cytosol preparations are associated with the 90-kDa heat shock protein hsp90, but the study of how hsp90 affects receptor function has been held back by the inability to reassociate steroid receptors with hsp90 in cell-free systems. Recently we showed (Dalman, F.C., Bresnick, E. H., Patel, P. D., Perdew, G. H., Watson, S. J., and Pratt, W. B. (1989) J. Biol. Chem. 264, 19815-19821) that glucocorticoid receptors translated in rabbit reticulocyte lysate bind to… CONTINUE READING