Structural and functional preservation of specific sequences of DNA and mRNA in apoptotic bodies from ES cells

@article{Andollo2005StructuralAF,
  title={Structural and functional preservation of specific sequences of DNA and mRNA in apoptotic bodies from ES cells},
  author={Noelia Andollo and Mar{\'i}a Dolores Boyano and Ricardo O Andrade and Mar{\'i}a M Zalduendo and Cristina Eguiz{\'a}bal and Aintzane Asumendi and Jon Arlucea and Juan Ar{\'e}chaga},
  journal={Apoptosis},
  year={2005},
  volume={10},
  pages={417-428}
}
Retinoic acid-induced apoptosis of embryonic stem (ES) cells is an experimental system which resembles the physiological programmed cell death that occurs during differentiation in embryonic development. Our aim was to analyze the involvement of epigenetic modifications such as DNA methylation and chromatin structure in the apoptotic process and to investigate the metabolic activity of apoptotic bodies. We found a relationship between DNA methylation and apoptosis, shown by a dose-dependent… CONTINUE READING
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