Structural and functional neuroplasticity in human learning of spatial routes


Recent findings with both animals and humans suggest that decreases in microscopic movements of water in the hippocampus reflect short-term neuroplasticity resulting from learning. Here we examine whether such neuroplastic structural changes concurrently alter the functional connectivity between hippocampus and other regions involved in learning. We collected both diffusion-weighted images and fMRI data before and after humans performed a 45min spatial route-learning task. Relative to a control group with equal practice time, there was decreased diffusivity in the posterior-dorsal dentate gyrus of the left hippocampus in the route-learning group accompanied by increased synchronization of fMRI-measured BOLD signal between this region and cortical areas, and by changes in behavioral performance. These concurrent changes characterize the multidimensionality of neuroplasticity as it enables human spatial learning.

DOI: 10.1016/j.neuroimage.2015.10.015

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@article{Keller2016StructuralAF, title={Structural and functional neuroplasticity in human learning of spatial routes}, author={Timothy A. Keller and Marcel Adam Just}, journal={NeuroImage}, year={2016}, volume={125}, pages={256-266} }