Structural and functional investigation of the intermolecular interaction between NRPS adenylation and carrier protein domains.

Abstract

Nonribosomal peptide synthetases (NRPSs) are modular proteins that produce peptide antibiotics and siderophores. These enzymes act as catalytic assembly lines where substrates, covalently bound to integrated carrier domains, are delivered to adjacent catalytic domains. The carrier domains are initially loaded by adenylation domains, which use two distinct… (More)
DOI: 10.1016/j.chembiol.2011.11.013

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