Structural and functional insights into enzymes of the vitamin K cycle.

  title={Structural and functional insights into enzymes of the vitamin K cycle.},
  author={Jian-Ke Tie and Darrel W. Stafford},
  journal={Journal of thrombosis and haemostasis : JTH},
  volume={14 2},
Vitamin K-dependent proteins require carboxylation of certain glutamates for their biological functions. The enzymes involved in the vitamin K-dependent carboxylation include: gamma-glutamyl carboxylase (GGCX), vitamin K epoxide reductase (VKOR) and an as-yet-unidentified vitamin K reductase (VKR). Due to the hydrophobicity of vitamin K, these enzymes are likely to be integral membrane proteins that reside in the endoplasmic reticulum. Therefore, structure-function studies on these enzymes have… CONTINUE READING
Highly Cited
This paper has 21 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 6 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 13 extracted citations

Similar Papers

Loading similar papers…