Structural and functional insights into enzymes of the vitamin K cycle.

@article{Tie2016StructuralAF,
  title={Structural and functional insights into enzymes of the vitamin K cycle.},
  author={Jian-Ke Tie and Darrel W. Stafford},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2016},
  volume={14 2},
  pages={236-47}
}
Vitamin K-dependent proteins require carboxylation of certain glutamates for their biological functions. The enzymes involved in the vitamin K-dependent carboxylation include: gamma-glutamyl carboxylase (GGCX), vitamin K epoxide reductase (VKOR) and an as-yet-unidentified vitamin K reductase (VKR). Due to the hydrophobicity of vitamin K, these enzymes are likely to be integral membrane proteins that reside in the endoplasmic reticulum. Therefore, structure-function studies on these enzymes have… CONTINUE READING
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