Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4.

@article{Shen2004StructuralAF,
  title={Structural and functional healing of critical-size segmental bone defects by transduced muscle-derived cells expressing BMP4.},
  author={Hsain-Chung Shen and Hairong Peng and Arvydas Ūsas and Brian Gearhart and F. Fu and Johnny Huard},
  journal={The journal of gene medicine},
  year={2004},
  volume={6 9},
  pages={984-91}
}
BACKGROUND Our previous studies have shown that muscle-derived cells, including a population of muscle stem cells, transduced with a retroviral vector expressing bone morphogenetic protein 4 (BMP4) can improve the healing of critical-size calvarial defects. However, we did not evaluate the functionality of the healed bone. The purpose of this study was to determine whether primary muscle-derived cells transduced with retroBMP4 can heal a long bone defect both structurally and functionally… CONTINUE READING

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