Structural and functional features of presynaptic afferents and their dependence on caspase-3 activity in rat hippocampal slices

@article{Kudryashova2011StructuralAF,
  title={Structural and functional features of presynaptic afferents and their dependence on caspase-3 activity in rat hippocampal slices},
  author={Irina V Kudryashova and Mikhail V. Onufriev and Natalia V. Gulyaeva},
  journal={Neurochemical Journal},
  year={2011},
  volume={6},
  pages={7-13}
}
We recorded focal responses in the CA1 field in rat hippocampal slices after the stimulation of Schaffer collaterals with testing stimuli of various intensities. The activities of caspase-3 and calpain were then measured in each slice. A comparison of the responses induced by the stimuli of the same intensity demonstrated that a decrease in the amplitude of the presynaptic component and the amplitude of the population spike was followed by a significant increase in caspase-3 activity. We did… CONTINUE READING

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NEUROCHEMICAL JOURNAL Vol. 6 No. 1 2012 STRUCTURAL AND FUNCTIONAL FEATURES OF PRESYNAPTIC AFFERENTS

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