Structural and functional features of factor XI.

@article{Gailani2009StructuralAF,
  title={Structural and functional features of factor XI.},
  author={David Gailani and Stephen Brent Smith},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2009},
  volume={7 Suppl 1},
  pages={
          75-8
        }
}
Factor XI (FXI) has structural and mechanistic features that distinguish it from other coagulation proteases. A relatively recent addition to vertebrate plasma coagulation, FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each… CONTINUE READING
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