Structural and functional evolution of the translocator protein (18 kDa).

  title={Structural and functional evolution of the translocator protein (18 kDa).},
  author={Jinjiang Fan and Petra Lindemann and Marc G J Feuilloley and Vassilios Papadopoulos},
  journal={Current molecular medicine},
  volume={12 4},
Translocator proteins (TSPO) are the products of a family of genes that is evolutionarily conserved from bacteria to humans and expressed in most mammalian tissues and cells. Human TSPO (18 kDa) is expressed at high levels in steroid synthesizing endocrine tissues where it localizes to mitochondria and functions in the first step of steroid formation, the transport of cholesterol into the mitochondria. TSPO expression is elevated in cancerous tissues and during tissue injury, which has lead to… CONTINUE READING

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