Structural and functional coupling of cardiac myocytes and fibroblasts.

  title={Structural and functional coupling of cardiac myocytes and fibroblasts.},
  author={Patrizia Camelliti and Colin Richard Green and Peter Kohl},
  journal={Advances in cardiology},
Cardiac myocytes and fibroblasts form extensive networks in the heart, with numerous anatomical contacts between cells. Fibroblasts, obligatory components of the extracellular matrix, represent the majority of cells in the normal heart, and their number increases with aging and during disease. The myocyte network, coupled by gap junctions, is generally believed to be electrically isolated from fibroblasts in vivo. In culture, however, the heterogeneous cell types form functional gap junctions… CONTINUE READING

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