Structural and functional consequences of the STAT5BN642H driver mutation

  title={Structural and functional consequences of the STAT5BN642H driver mutation},
  author={Elvin D de Araujo and Fettah Erdogan and Heidi A Neubauer and Deniz Meneksedag-Erol and Pimyupa Manaswiyoungkul and Mohammad S Eram and Hyuk-Soo Seo and Abdul K Qadree and Johan Israelian and Anna Orlova and Tobias Suske and Ha Thi Thanh Pham and Auke Boersma and Simone Tangermann and Lukas Kenner and Thomas R{\"u}licke and Aiping Dong and Manimekalai Ravichandran and Peter J. C. Brown and Gerald F Audette and Sarah Rauscher and Sirano dhe-Paganon and Richard Moriggl and Patrick T Gunning},
  booktitle={Nature Communications},
Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the aggressive nature of STAT5BN642H in driving T-cell neoplasia upon hematopoietic expression in transgenic mice, revealing evidence of multiple T-cell subset organ infiltration. Notably, we demonstrate… CONTINUE READING


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