Structural and functional consequences of the STAT5BN642H driver mutation

@inproceedings{Araujo2019StructuralAF,
  title={Structural and functional consequences of the STAT5BN642H driver mutation},
  author={Elvin D de Araujo and Fettah Erdogan and Heidi A Neubauer and Deniz Meneksedag-Erol and Pimyupa Manaswiyoungkul and Mohammad S Eram and Hyuk-Soo Seo and Abdul K Qadree and Johan Israelian and Anna Orlova and Tobias Suske and Ha Thi Thanh Pham and Auke Boersma and Simone Tangermann and Lukas Kenner and Thomas R{\"u}licke and Aiping Dong and Manimekalai Ravichandran and Peter J. C. Brown and Gerald F Audette and Sarah Rauscher and Sirano dhe-Paganon and Richard Moriggl and Patrick T Gunning},
  booktitle={Nature Communications},
  year={2019}
}
Hyper-activated STAT5B variants are high value oncology targets for pharmacologic intervention. STAT5BN642H, a frequently-occurring oncogenic driver mutation, promotes aggressive T-cell leukemia/lymphoma in patient carriers, although the molecular origins remain unclear. Herein, we emphasize the aggressive nature of STAT5BN642H in driving T-cell neoplasia upon hematopoietic expression in transgenic mice, revealing evidence of multiple T-cell subset organ infiltration. Notably, we demonstrate… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 81 REFERENCES

Twins with different personalities: STAT5B—but not STAT5A—has a key role in BCR/ABL-induced leukemia

Sebastian Kollmann, Eva Grundschober, +13 authors Veronika Sexl
  • Leukemia
  • 2019
VIEW 1 EXCERPT

Discovery of novel drug sensitivities in T-PLL by highthroughput ex vivo drug testing and mutation profiling

Andersson, I E.
  • Leukemia 32,
  • 2018