Structural and functional consequences of glutamine tract variation in the androgen receptor.

@article{Buchanan2004StructuralAF,
  title={Structural and functional consequences of glutamine tract variation in the androgen receptor.},
  author={G. Buchanan and M. Yang and A. Cheong and J. Harris and R. Irvine and P. Lambert and N. Moore and Michael P Raynor and P. Neufing and G. Coetzee and W. Tilley},
  journal={Human molecular genetics},
  year={2004},
  volume={13 16},
  pages={
          1677-92
        }
}
The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat region, (CAG)(n), in its N-terminal transactivation domain (NTD) that encodes a polyglutamine (polyQ) tract in the receptor protein. Whereas the length of the CAG repeat ranges from 6 to 39 in healthy individuals, the variations in repeat length both within and outside the normal range are associated with disease, including impaired spermatogenesis and Kennedy's disease, and with the risk of developing breast and… Expand
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References

SHOWING 1-10 OF 95 REFERENCES
The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function.
  • 1,111
Implications of a polyglutamine tract in the function of the human androgen receptor.
  • 68
The polyglycine and polyglutamine repeats in the androgen receptor gene in Japanese and Caucasian populations.
  • 33
The androgen receptor gene GGN microsatellite and prostate cancer risk.
  • E. Platz, E. Giovannucci, +5 authors P. Kantoff
  • Biology, Medicine
  • Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
  • 1998
  • 101
  • PDF
Polymorphism of homopolymeric glutamines in coactivators for nuclear hormone receptors.
  • 28
...
1
2
3
4
5
...