Structural and functional characterization of two alpha-synuclein strains

@inproceedings{Bousset2013StructuralAF,
  title={Structural and functional characterization of two alpha-synuclein strains},
  author={Luc Bousset and Laura Pieri and Gemma Ruiz-Arlandis and Julia Gath and Poul Henning Jensen and Birgit Habenstein and Karine Madiona and Vincent Olieric and Anja B{\"o}ckmann and Beat H Meier and Ronald Melki},
  booktitle={Nature communications},
  year={2013}
}
α-Synuclein aggregation is implicated in a variety of diseases including Parkinson's disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy. The association of protein aggregates made of a single protein with a variety of clinical phenotypes has been explained for prion diseases by the existence of different strains that propagate through the infection pathway. Here we structurally and functionally characterize two polymorphs of α-synuclein. We present evidence… CONTINUE READING
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