Structural and functional characterization of the Bacillus megaterium uvrBA locus and generation of UV-sensitive mutants

@article{Nahrstedt2004StructuralAF,
  title={Structural and functional characterization of the Bacillus megaterium uvrBA locus and generation of UV-sensitive mutants},
  author={Hannes Nahrstedt and Friedhelm Meinhardt},
  journal={Applied Microbiology and Biotechnology},
  year={2004},
  volume={65},
  pages={193-199}
}
The Bacillus megaterium genes uvrB and uvrA, encoding two subunits of the (A)BC excinuclease, which is responsible for nucleotide excision repair, were isolated and functionally characterized. RNA analyses revealed co-transcription of both genes probably forming a bicistronic operon. Expression of uvrB and uvrA was inducible by the DNA-damaging agent mitomycin C. This finding agrees with the presence of a potential DinR box within the uvrBA promoter. Single inactivation of uvrB or uvrA as well… CONTINUE READING
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