Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium.

@article{L2012StructuralAF,
  title={Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium.},
  author={Wei L{\"u} and Nikola J Schwarzer and Juan Du and Elke Gerbig-Smentek and Susana L A Andrade and Oliver Einsle},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 45},
  pages={18395-400}
}
Nitrite (NO(2)(-)) is a central intermediate in the nitrogen metabolism of microorganisms and plants, and is used as a cytotoxin by macrophages as part of the innate immune response. The bacterial membrane protein NirC acts as a specific channel to facilitate the transport of nitrite anions across lipid bilayers for cytoplasmic detoxification. Despite NirC's importance in nitrogen metabolism and in the pathogenicity of enteric bacteria, available biochemical data are scarce. Here we present a… CONTINUE READING
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