Structural and functional characterization of human Iba proteins

@article{Schulze2008StructuralAF,
  title={Structural and functional characterization of human Iba proteins},
  author={J. Schulze and C. Quedenau and Y. Roske and T. Adam and H. Sch{\"u}ler and J. Behlke and A. Turnbull and V. Sievert and C. Scheich and U. Mueller and U. Heinemann and K. B{\"u}ssow},
  journal={The FEBS Journal},
  year={2008},
  volume={275}
}
Iba2 is a homolog of ionized calcium‐binding adapter molecule 1 (Iba1), a 17‐kDa protein that binds and cross‐links filamentous actin (F‐actin) and localizes to membrane ruffles and phagocytic cups. Here, we present the crystal structure of human Iba2 and its homodimerization properties, F‐actin cross‐linking activity, cellular localization and recruitment upon bacterial invasion in comparison with Iba1. The Iba2 structure comprises two central EF‐hand motifs lacking bound Ca2+. Iba2… Expand
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