Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ.

@article{Liang2014StructuralAF,
  title={Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ.},
  author={Yajing Liang and Zengqiang Gao and Fei Wang and Yangli Zhang and Yuhui Dong and Quansheng Liu},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 30},
  pages={21191-202}
}
Toxin YafQ functions as a ribonuclease in the dinJ-yafQ toxin-antitoxin system of Escherichia coli. Antitoxin DinJ neutralizes YafQ-mediated toxicity by forming a stable protein complex. Here, crystal structures of the (DinJ)2-(YafQ)2 complex and the isolated YafQ toxin have been determined. The structure of the heterotetrameric complex (DinJ)2-(YafQ)2 revealed that the N-terminal region of DinJ folds into a ribbon-helix-helix motif and dimerizes for DNA recognition, and the C-terminal portion… CONTINUE READING

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