Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).

@article{Mas2011StructuralAF,
  title={Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF).},
  author={Caroline Mas and Mathieu Lussier-Price and Shefali Soni and Thomas O Morse and Genevi{\`e}ve Arseneault and Paola Di Lello and Julien Lafrance-Vanasse and James J Bieker and James G Omichinski},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 26},
  pages={10484-9}
}
Erythroid Krüppel-like factor (EKLF) plays an important role in erythroid development by stimulating β-globin gene expression. We have examined the details by which the minimal transactivation domain (TAD) of EKLF (EKLFTAD) interacts with several transcriptional regulatory factors. We report that EKLFTAD displays homology to the p53TAD and, like the p53TAD, can be divided into two functional subdomains (EKLFTAD1 and EKLFTAD2). Based on sequence analysis, we found that EKLFTAD2 is conserved in… CONTINUE READING