Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor.

@article{Iwema2007StructuralAF,
  title={Structural and functional characterization of a novel type of ligand-independent RXR-USP receptor.},
  author={Thomas Iwema and Isabelle M. L. Billas and Yannick Beck and F Bonneton and H{\'e}l{\`e}ne Nierengarten and Arnaud Chaumot and Geoff Richards and Vincent Laudet and Dino Moras},
  journal={The EMBO journal},
  year={2007},
  volume={26 16},
  pages={3770-82}
}
Retinoid X receptor (RXR) and Ultraspiracle (USP) play a central role as ubiquitous heterodimerization partners of many nuclear receptors. While it has long been accepted that a wide range of ligands can activate vertebrate/mollusc RXRs, the existence and necessity of specific endogenous ligands activating RXR-USP in vivo is still matter of intense debate. Here we report the existence of a novel type of RXR-USP with a ligand-independent functional conformation. Our studies involved Tribolium… CONTINUE READING
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