Structural and functional characterization of sapovirus RNA-dependent RNA polymerase.

@article{Fullerton2007StructuralAF,
  title={Structural and functional characterization of sapovirus RNA-dependent RNA polymerase.},
  author={Stephen W B Fullerton and Martina Blaschke and Bruno Coutard and Julia Gebhardt and Alexander E. Gorbalenya and Bruno Canard and Paul A. Tucker and Jacques Rohayem},
  journal={Journal of virology},
  year={2007},
  volume={81 4},
  pages={1858-71}
}
Sapoviruses are one of the major agents of acute gastroenteritis in childhood. They form a tight genetic cluster (genus) in the Caliciviridae family that regroups both animal and human pathogenic strains. No permissive tissue culture has been developed for human sapovirus, limiting its characterization to surrogate systems. We report here on the first extensive characterization of the key enzyme of replication, the RNA-dependent RNA polymerase (RdRp) associated with the 3D(pol)-like protein… CONTINUE READING