Structural and functional changes of rat exocrine pancreas exposed to nicotine.

  title={Structural and functional changes of rat exocrine pancreas exposed to nicotine.},
  author={Parimal Chowdhury and Ryuichiro Doi and Akira Tangoku and Phillip L. Rayford},
  journal={International journal of pancreatology : official journal of the International Association of Pancreatology},
  volume={18 3},
Nicotine, an addictive agent in cigarette smoking, has been implicated in the etiology of pancreatitis and pancreatic carcinoma. Very little experimental data are, however, available regarding the effects of nicotine on the structural and functional changes in the exocrine pancreas. Two groups of rats divided into control and nicotine exposed were used. The animals in the nicotine group were maintained for 28 d with ad libitum water containing 0.77 mM of nicotine. At term, the animals were… CONTINUE READING

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