Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig.

@article{Berecek1977StructuralAF,
  title={Structural and functional changes in vascular resistance and reactivity in the deoxycorticosterone acetate (DOCA)-hypertensive pig.},
  author={Kathleen H. Berecek and David F. Bohr},
  journal={Circulation research},
  year={1977},
  volume={40 5 Suppl 1},
  pages={I146-52}
}
The development of altered vascular resistance and reactivity was characterized in a new model of hypertension, the deoxycorticosterone acetate (DOCA)-hypertensive pig. Terminal hindlimb perfusion studies were carried out on pigs (young uninephrectomized males) approximately 50 days after implantation of DOCA or control Silastic strips. Data from these studies showed that hypertensive vascular beds (n = 5) had significantly greater (P less than 0.005) resistances than controls (n = 9) both… CONTINUE READING