Structural and functional changes in the airway smooth muscle of asthmatic subjects.

@article{Seow1998StructuralAF,
  title={Structural and functional changes in the airway smooth muscle of asthmatic subjects.},
  author={Chun Y Seow and R. Robert Schellenberg and Peter D. Par{\'e}},
  journal={American journal of respiratory and critical care medicine},
  year={1998},
  volume={158 5 Pt 3},
  pages={S179-86}
}
It has been recognized since the early 1920s that the amount of smooth muscle in asthmatic subjects' airways is markedly increased. More recent studies have confirmed that in fatal asthma there is a significant increase in the thickness of airway smooth muscle. For subjects who have had asthma and who died for other reasons or had a lobectomy, the increase in muscle layer thickness is less striking. An increase in smooth muscle mass could have a dual effect on airway narrowing: one due to the… CONTINUE READING