Structural and functional changes in salivary glands during aging

  title={Structural and functional changes in salivary glands during aging},
  author={S. K. Kim and E. A. Dale Allen},
  journal={Microscopy Research and Technique},
Various salivary glands in senescent humans and other animals have been examined extensively to characterize the structural and functional changes that occur during aging. Although a wide range of different structural changes, involving both the parenchymal and stromal tissues, have been described, it is unclear how any of these changes affects the function of the salivary glands. One major change in structure is the reduction in the volume of acini with a concomitant increase in the ductal… 

Age associated decrease of sialin in salivary glands

  • L. LiH. Wang S. Wang
  • Biology, Medicine
    Biotechnic & histochemistry : official publication of the Biological Stain Commission
  • 2018
It was found that the protein and mRNA expression levels of sialin decreased with aging, and the expression of sIALin in the striated and excretory ducts of both mouse and human glands were reduced with age.

Age-dependent changes in insulin-like immunoreactivity in rat submandibular salivary glands.

The amount of ILI in the submandibular glands of young adult rats was found to be doubled in the post-natal period until the age of puberty and was maintained in senescence, further supporting previous indications that ILI is being synthesized in situ.

Morphological Changes in the Rat Sublingual Gland Parenchyma with Aging

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Differences with respect to protein and glycosylation profiles between 1-month-old rats and older ones could be caused by a modification of the diet composition as well as by the functional and morphological maturation of the rat submandibular gland.

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  • T. Kotyk
  • Medicine
    Microscopy research and technique
  • 2016
In the intralobular duct of the SMG in experimental DM dystrophic changes of different intensity occur in the granular and striated ducts on the 14th day and in the intercalation ducts only since the 42nd day of the experiment.

Impact of Experimental Hyperlipidemia on Histology of Major Salivary Glands Deneysel Hiperlipideminin Büyük Tükürük Bezlerinin Histolojisi Üzerine Etkisi

High-fat diet caused intracellular lipid accumulation in the parotid and sublingual glands without any structural alteration, and submandibular gland exerted a partial resistance to intrace cellular lipid accumulation.

Ultrastructure of the Parotid Salivary Gland in the Greater Cane Rats (Thryonomys Swinderianus)

  • C. Igbokwe
  • Biology
    Journal of microscopy and ultrastructure
  • 2018
The parotid glands of adult male African greater cane rat were examined by light microscopy (semi-thin sections) and transmission electron microscopy and the functional significance of these structures is discussed.



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The most prominent change noted in these cells is the progressive increase in the amount of lipofuscin granules with age, which appears to be related to the reduced level of cellular secretory activity in the glands of older rats.

Age-related changes in structure of labial minor salivary glands.

The results clearly indicate that an age- and sex-matched control group is mandatory when salivary gland changes associated with systemic diseases are evaluated.

Morphometric study of histological changes in sublabial salivary glands due to aging process.

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Evidence indicates an average loss of a quarter of the relative secretory cell volume between childhood and old age, by which time the more extremely affected glands may have lost one half.

Age-related changes in EGF and protease in submandibular glands of C57BL/6J mice.

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Changes with senescence in the fine structure of the granular convoluted tubule of the submandibular gland of the mouse.

  • E. Gresik
  • Biology
    The American journal of anatomy
  • 1989
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