Structural and functional changes in salivary glands during aging

@article{Kim1994StructuralAF,
  title={Structural and functional changes in salivary glands during aging},
  author={S. Kim and E. Allen},
  journal={Microscopy Research and Technique},
  year={1994},
  volume={28}
}
  • S. Kim, E. Allen
  • Published 1994
  • Biology, Medicine
  • Microscopy Research and Technique
Various salivary glands in senescent humans and other animals have been examined extensively to characterize the structural and functional changes that occur during aging. Although a wide range of different structural changes, involving both the parenchymal and stromal tissues, have been described, it is unclear how any of these changes affects the function of the salivary glands. One major change in structure is the reduction in the volume of acini with a concomitant increase in the ductal… Expand
Age associated decrease of sialin in salivary glands
  • L. Li, H. Wang, +6 authors S. Wang
  • Biology, Medicine
  • Biotechnic & histochemistry : official publication of the Biological Stain Commission
  • 2018
TLDR
It was found that the protein and mRNA expression levels of sialin decreased with aging, and the expression of sIALin in the striated and excretory ducts of both mouse and human glands were reduced with age. Expand
Age-dependent changes in insulin-like immunoreactivity in rat submandibular salivary glands.
TLDR
The amount of ILI in the submandibular glands of young adult rats was found to be doubled in the post-natal period until the age of puberty and was maintained in senescence, further supporting previous indications that ILI is being synthesized in situ. Expand
Morphological Changes in the Rat Sublingual Gland Parenchyma with Aging
TLDR
Findings indicate that the rat sublingual gland accumulates amyloid protein in the parenchyma and changes the properties of secretory granules of the acinar cells in the serous demilune with aging, though apoptosis of theParenchymal cells and the decrease of the gland weight are slight. Expand
Rat submandibular gland during the maturation process: changes in enzyme activities, protein and lectin-binding profiles.
TLDR
Differences with respect to protein and glycosylation profiles between 1-month-old rats and older ones could be caused by a modification of the diet composition as well as by the functional and morphological maturation of the rat submandibular gland. Expand
Age-related histomorphometric changes in labial salivary glands with special reference to the Acinar component
TLDR
A marked decrease in the V(v) of seromucous acinar cells accompanied by a lower decrease inThe V( v) of mucousAcinar cells may explain age-related changes in LSG secretion and could bear important implications regarding functional age- related changes of these glands. Expand
Morphology of the intralobular duct of the submandibular gland in rats in case of experimental diabetes mellitus
  • T. Kotyk
  • Biology, Medicine
  • Microscopy research and technique
  • 2016
TLDR
In the intralobular duct of the SMG in experimental DM dystrophic changes of different intensity occur in the granular and striated ducts on the 14th day and in the intercalation ducts only since the 42nd day of the experiment. Expand
Impact of Experimental Hyperlipidemia on Histology of Major Salivary Glands Deneysel Hiperlipideminin Büyük Tükürük Bezlerinin Histolojisi Üzerine Etkisi
TLDR
High-fat diet caused intracellular lipid accumulation in the parotid and sublingual glands without any structural alteration, and submandibular gland exerted a partial resistance to intrace cellular lipid accumulation. Expand
Age-related changes in proliferative markers in labial salivary glands: a study of argyrophilic nucleolar organizer regions (AgNORs) and Ki-67
TLDR
It is suggested that age-related changes in AgNOR parameters could reflect changes in the metabolic cell activity rather than changes in their proliferative capacity as reflected by AgNOR and Ki-67 parameters. Expand
Ultrastructure of the Parotid Salivary Gland in the Greater Cane Rats (Thryonomys Swinderianus)
  • C. Igbokwe
  • Biology, Medicine
  • Journal of microscopy and ultrastructure
  • 2018
TLDR
The parotid glands of adult male African greater cane rat were examined by light microscopy (semi-thin sections) and transmission electron microscopy and the functional significance of these structures is discussed. Expand
Quantitative age-related differences in human sublingual gland.
TLDR
The decrease of parenchyma accompanied by an increase of stroma observed here in SLG is a common feature of aging in human salivary glands. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 65 REFERENCES
Changes in the secretory acinar cells of the rat parotid gland during aging
  • S. Kim
  • Biology, Medicine
  • The Anatomical record
  • 1984
TLDR
The most prominent change noted in these cells is the progressive increase in the amount of lipofuscin granules with age, which appears to be related to the reduced level of cellular secretory activity in the glands of older rats. Expand
Age-related changes in structure of labial minor salivary glands.
TLDR
The results clearly indicate that an age- and sex-matched control group is mandatory when salivary gland changes associated with systemic diseases are evaluated. Expand
Morphometric study of histological changes in sublabial salivary glands due to aging process.
The sublabial salivary glands were studied by morphometric methods in 68 healthy volunteers to establish possible changes related to age in those tissue components that are affected in Sjögren'sExpand
Replacement of functional parenchymal cells by fat and connective tissue in human submandibular salivary glands: an age-related change.
TLDR
Evidence indicates an average loss of a quarter of the relative secretory cell volume between childhood and old age, by which time the more extremely affected glands may have lost one half. Expand
Quantitative age changes in the histological structure of human submandibular salivary glands.
  • J. Scott
  • Biology, Medicine
  • Archives of oral biology
  • 1977
TLDR
Findings suggested there was an acceleration in the rates of volumetric tissue changes in the two final decades, and a progressive increase in vascular volume was related to increasing levels of degenerative vascular disease which may, through ischaemia, bear some causal relation to the ageing atrophy of parenchyma. Expand
A biochemical analysis of parotid and submandibular salivary gland function with age after simultaneous stimulation with pilocarpine and isoproterenol in female NIA Fischer 344 rats.
TLDR
It seemed that the submandibular gland followed the same picture with age as the parotid gland, with a specific decline in the biosynthesis of single secretory proteins. Expand
Amylase mRNA synthesis and ageing in rat parotid glands following isoproterenol-stimulated secretion.
TLDR
It appears that parotid acinar cells from old rats can be stimulated to synthesize secretory proteins at an increased rate, although it remains to be determined what causes the reduced rate of protein synthesis in unstimulated glands in old rats. Expand
Effects of age on diabetes- and insulin-induced changes in pancreatic levels of α-amylase and its mRNA
TLDR
Results indicate that the pancreatic cells remain effective during aging in their transcriptional activity for functional amylase mRNA in response to an exogenous stimulus of insulin. Expand
Age-related changes in EGF and protease in submandibular glands of C57BL/6J mice.
The submandibular glands of male C57BL/6J mice were studied cytologically and chemically at the following ages (months): 1-1.5, 6-8, 12-13, 28-32. The relative proportion of granular convolutedExpand
Changes with senescence in the fine structure of the granular convoluted tubule of the submandibular gland of the mouse.
  • E. Gresik
  • Biology, Medicine
  • The American journal of anatomy
  • 1989
TLDR
These fine structural changes are consistent with impairments with advanced age in synthesis and posttranslational processing of secretory products by affected GCT cells, and are also consistent with crinophagic activity. Expand
...
1
2
3
4
5
...