Structural and functional basis for (S)-allantoin formation in the ureide pathway.

  title={Structural and functional basis for (S)-allantoin formation in the ureide pathway.},
  author={Kwangsoo Kim and Jinseo Park and Sangkee Rhee},
  journal={The Journal of biological chemistry},
  volume={282 32},
The ureide pathway, which mediates the oxidative degradation of uric acid to (S)-allantoin, represents the late stage of purine catabolism in most organisms. The details of uric acid metabolism remained elusive until the complete pathway involving three enzymes was recently identified and characterized. However, the molecular details of the exclusive production of one enantiomer of allantoin in this pathway are still undefined. Here we report the crystal structure of 2-oxo-4-hydroxy-4-carboxy-5… CONTINUE READING