Structural and functional associations of apical junctions with cytoskeleton.

  title={Structural and functional associations of apical junctions with cytoskeleton.},
  author={Jun Miyoshi and Yoshimi Takai},
  journal={Biochimica et biophysica acta},
  volume={1778 3},
Actin dynamics play multiple roles in promoting cell movement, changing cell shapes, and establishing intercellular adhesion. Cell contact events are involved in tissue morphogenesis, immune responses, and cancer cell invasion. In epithelial cells, cell-cell contacts mature to form apical junctions with which the actin cytoskeleton physically associates. Living cell imaging shows, however, that the apical junctional complex is less dynamically regulated than the actin cytoskeleton, indicating… CONTINUE READING
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