Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism.

@article{Nasuno2013StructuralAF,
  title={Structural and functional analysis of the yeast N-acetyltransferase Mpr1 involved in oxidative stress tolerance via proline metabolism.},
  author={Ryo Nasuno and Yoshinori Hirano and Takafumi Itoh and Toshio Hakoshima and Takao Hibi and Hiroshi Takagi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 29},
  pages={11821-6}
}
Mpr1 (sigma1278b gene for proline-analog resistance 1), which was originally isolated as N-acetyltransferase detoxifying the proline analog L-azetidine-2-carboxylate, protects yeast cells from various oxidative stresses. Mpr1 mediates the L-proline and L-arginine metabolism by acetylating L-Δ(1)-pyrroline-5-carboxylate, leading to the L-arginine-dependent production of nitric oxide, which confers oxidative stress tolerance. Mpr1 belongs to the Gcn5-related N-acetyltransferase (GNAT) superfamily… CONTINUE READING

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