Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H.

@article{Alsenz1985StructuralAF,
  title={Structural and functional analysis of the complement component factor H with the use of different enzymes and monoclonal antibodies to factor H.},
  author={J Alsenz and Th. F. Schulz and John D. Lambris and Robert B Sim and Manfred Paul Dierich},
  journal={The Biochemical journal},
  year={1985},
  volume={232 3},
  pages={841-50}
}
The action of six different enzymes on the function and structure of Factor H was investigated by use of sodium dodecyl sulphate/polyacrylamide-gel electrophoresis, haemagglutination, two enzyme-linked immunosorbent assay systems and an assay for Factor I cofactor activity. Six monoclonal antibodies directed against the 38 kDa tryptic fragment of Factor H [which contains the binding site for C3b (a 180 kDa fragment of the third component of complement) and the cofactor activity] were also used… CONTINUE READING
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