Structural and functional analysis of the MutS C-terminal tetramerization domain

@article{Manelyt2006StructuralAF,
  title={Structural and functional analysis of the MutS C-terminal tetramerization domain},
  author={Laura Manelytė and Claus Urbanke and Luis Giron-Monzon and Peter Friedhoff},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={5270 - 5279}
}
The Escherichia coli DNA mismatch repair (MMR) protein MutS is essential for the correction of DNA replication errors. In vitro, MutS exists in a dimer/tetramer equilibrium that is converted into a monomer/dimer equilibrium upon deletion of the C-terminal 53 amino acids. In vivo and in vitro data have shown that this C-terminal domain (CTD, residues 801-853) is critical for tetramerization and the function of MutS in MMR and anti-recombination. We report the expression, purification and… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 35 references

Similar Papers

Loading similar papers…