Structural and functional analysis of the BMP-4 promoter in early embryos of Xenopus laevis

  title={Structural and functional analysis of the BMP-4 promoter in early embryos of Xenopus laevis},
  author={A. Metz and S. Kn{\"o}chel and P. Buechler and M. K{\"o}ster and W. Knöchel},
  journal={Mechanisms of Development},
  • A. Metz, S. Knöchel, +2 authors W. Knöchel
  • Published 1998
  • Biology, Medicine
  • Mechanisms of Development
  • The Xenopus laevis BMP-4 gene shows an evolutionary conserved structure containing two coding exons and a leader exon. The transcripts which are detected after zygotic activation of the gene in ventral mesoderm of late blastula stage embryos do either contain the leader exon or begin within the first intron. Luciferase reporter/promoter studies revealed multiple elements being required for the activation and for the spatial control of transcription. These elements are located within the… CONTINUE READING
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