Structural and functional analysis of natrin, a venom protein that targets various ion channels.

@article{Wang2006StructuralAF,
  title={Structural and functional analysis of natrin, a venom protein that targets various ion channels.},
  author={Feng Wang and He Li and Ming-na Liu and Hui Song and Hong-mei Han and Qiong-ling Wang and Chang-chen Yin and Yuan-cong Zhou and Zhi Qi and Yu-yan Shu and Zheng-jiong Lin and Tao Jiang},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={351 2},
  pages={443-8}
}
Cysteine-rich secretory proteins (CRISPs) are secreted single-chain proteins found in different sources. Natrin is a member of the CRISP family purified from the snake venom of Naja naja atra, which has been reported as a BKca channel blocker. In our study, crystals of natrin were obtained in two different crystal forms and the structure of one of them was solved at a resolution of 1.68A. Our electrophysiological experiments indicated that natrin can block the ion channel currents of the… CONTINUE READING