Structural and functional analysis of horse cathelicidin peptides.

  title={Structural and functional analysis of horse cathelicidin peptides.},
  author={Barbara Skerlavaj and Marco Scocchi and Renato Gennaro and Angela Risso and Margherita Zanetti},
  journal={Antimicrobial agents and chemotherapy},
  volume={45 3},
Cathelicidin-derived antimicrobial peptides are a component of the peptide-based host defense of neutrophils and epithelia, with a widespread distribution in mammals. We recently reported the cDNA sequences of three putative horse myeloid cathelicidins, named eCATH-1, -2, and -3. A Western analysis was performed to investigate their presence in neutrophils and processing to mature peptides. eCATH-2 and eCATH-3, but not eCATH-1, were found to be present in uncleaved forms in horse neutrophils… CONTINUE READING


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