Structural and functional analysis of hypoxia-inducible factor 1.

  title={Structural and functional analysis of hypoxia-inducible factor 1.},
  author={Gregg L Semenza and Faton A Agani and George Booth and J A Forsythe and Narayan V. Iyer and Bin Jiang and Sandra W Leung and Rachel Roe and Charles Wiener and Aimee Y Yu},
  journal={Kidney international},
  volume={51 2},
Hypoxia-inducible factor 1 (HIF-1) is a basic helix-loop-helix protein that activates transcription of hypoxia-inducible genes, including those encoding: erythropoietin, vascular endothelial growth factor, heme oxygenase-1, inducible nitric oxide synthase, and the glycolytic enzymes aldolase A, enolase 1, lactate dehydrogenase A, phosphofructokinase I, and phosphoglycerate kinase 1. Hypoxia response elements from these genes consist of a HIF-1 binding site (that contains the core sequence 5… CONTINUE READING
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