Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus

@article{Laing2019StructuralAF,
  title={Structural and functional analyses reveal promiscuous and species specific use of ephrin receptors by Cedar virus},
  author={Eric D. Laing and Chanakha K. Navaratnarajah and Sofia Cheliout Da Silva and Stephanie R Petzing and Yan Xu and Spencer L. Sterling and Glenn A. Marsh and Lin‐Fa Wang and Moushimi Amaya and Dimitar B. Nikolov and Roberto Cattaneo and Christopher C. Broder and Kai Xu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2019},
  volume={116},
  pages={20707 - 20715}
}
  • E. Laing, C. Navaratnarajah, Kai Xu
  • Published 23 September 2019
  • Biology
  • Proceedings of the National Academy of Sciences of the United States of America
Significance Nipah and Hendra viruses are pathogenic zoonotic henipaviruses, transmitted from wildlife to humans, and potential epidemic threats. Zoonoses from wildlife hosts to humans require overcoming barriers that limit cross-species transmission. Successful usage of virus entry receptors represents a bottleneck to zoonosis. Conserved ephrins are recognized entry receptors for henipaviruses like Nipah virus. Here, we characterize the ephrin entry receptor usage of Cedar virus (CedV), a… 

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