Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells.

@article{Moh2005StructuralAF,
  title={Structural and functional analyses of a novel ig-like cell adhesion molecule, hepaCAM, in the human breast carcinoma MCF7 cells.},
  author={Mei Chung Moh and Chunli Zhang and Chun Li Luo and Lay Hoon Lee and Shali Shen},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 29},
  pages={
          27366-74
        }
}
We have recently identified a novel gene, hepaCAM, in liver that encodes a cell adhesion molecule of the immunoglobulin superfamily. In this study, we examined the characteristics of hepaCAM protein and the relationship between its structure and function, in particular its adhesive properties. The wild-type and the cytoplasmic domain-truncated mutants of hepaCAM were transfected into the human breast carcinoma MCF7 cells, and the physiological and biological properties were assessed… CONTINUE READING
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