Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects.

@article{Deng2004StructuralAF,
  title={Structural and functional abnormalities in the islets isolated from type 2 diabetic subjects.},
  author={Shaoping Deng and Marko Z. Vatamaniuk and Xiaolun Huang and Nicolai M. Doliba and M Y Lian and Adam Frank and Ergun H Velidedeoglu and Niraj M Desai and Brigitte Koeberlein and Bryan Wolf and Clyde F. Barker and Ali Naji and Franz M. Matschinsky and James F. Markmann},
  journal={Diabetes},
  year={2004},
  volume={53 3},
  pages={624-32}
}
Type 2 diabetic subjects manifest both disordered insulin action and abnormalities in their pancreatic islet cells. Whether the latter represents a primary defect or is a consequence of the former is unknown. To examine the beta-cell mass and function of islets from type 2 diabetic patients directly, we isolated islets from pancreata of type 2 diabetic… CONTINUE READING