Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: II. Evolutionary analysis of protein and gene structures.

@article{Yoshida1997StructuralAE,
  title={Structural and evolutionary studies on sterol 14-demethylase P450 (CYP51), the most conserved P450 monooxygenase: II. Evolutionary analysis of protein and gene structures.},
  author={Yuzo Yoshida and Mitsuhide Noshiro and Yuri Aoyama and Toru Kawamoto and Takashi Horiuchi and Osamu Gotoh},
  journal={Journal of biochemistry},
  year={1997},
  volume={122 6},
  pages={1122-8}
}
Phylogenetic analyses based on protein sequence data indicated that sterol 14-demethylase P450 (CYP51) and bacterial CYP51-like protein were joined into a distinctive evolutionary cluster, CYP51 cluster, within the CYP protein superfamily. The most probable branch topology of the CYP51 phylogenetic tree was (bacteria, (plants, (fungi, mammals))), which is comparable to the phylogeny of major kingdoms of living matter, suggesting that CYP51 has been conserved from the era of prokaryotic… CONTINUE READING
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