Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl‐prolyl cis‐trans isomerases

@article{Trandinh1992StructuralAE,
  title={Structural and evolutionary relationships among the immunophilins: two ubiquitous families of peptidyl‐prolyl cis‐trans isomerases},
  author={C. Christine Trandinh and Gerald M. Pao and Milton H. Saier},
  journal={The FASEB Journal},
  year={1992},
  volume={6},
  pages={3410 - 3420}
}
The immunophilins, protein receptors for the immunosuppressing drugs cyclosporin A and FK506 and related proteins from plants, fungi, and bacteria, have been analyzed structurally and evolutionarily. The cyclosporin A binding proteins (cyclophilins) represent one ubiquitous family of homologous proteins, and the FK506‐ and rapamycin‐binding proteins (FKBPs) constitute a second, unrelated family. Multiple sequence alignments of members of each of these two protein families define the highly… 

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