Structural and evolutionary characteristics of fish-specific TLR19.

  title={Structural and evolutionary characteristics of fish-specific TLR19.},
  author={Jinlan Wang and Zheng Zhang and Hui Fu and Shangli Zhang and Jing Liu and Fen Chang and Fang Li and Jing Zhao and Deling Yin},
  journal={Fish & shellfish immunology},
  volume={47 1},
Toll-like receptors (TLRs) are important pattern recognition receptors in the innate immune system of fish. Although ten years have passed since the first identification, the systematic knowledge about fish-specific TLR19 is still far insufficient. In present study, a phylogenetic analysis showed that TLR19 belonged to family 11, and clustered with TLR20 and TLR11/12 on the evolutionary tree. TLR20 is the closest paralogue of TLR19. The ectodomain of TLR19 contains 24 leucine-rich repeat (LRR… CONTINUE READING
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