Structural and energetic basis of protein kinetic destabilization in human phosphoglycerate kinase 1 deficiency.


Protein kinetic destabilization is a common feature of many human genetic diseases. Human phosphoglycerate kinase 1 (PGK1) deficiency is a rare genetic disease caused by mutations in the PGK1 protein, which often shows reduced kinetic stability. In this work, we have performed an in-depth characterization of the thermal stability of the wild type and four… (More)
DOI: 10.1021/bi301565m

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