Structural and dynamical characterization of the Miz-1 zinc fingers 5-8 by solution-state NMR.

Abstract

Myc-interacting zinc finger protein-1 (Miz-1) is a BTB/POZ transcription factor that activates the transcription of cytostatic genes, such as p15(INK4B) or p21(CIP1). The C-terminus of Miz-1 contains 13 consensus C2H2 zinc finger domains (ZF). ZFs 1-4 have been shown to interact with SMAD3/4, while the remaining ZFs are expected to bind the promoters of… (More)
DOI: 10.1007/s10858-013-9770-6

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