Structural and conformational aspects of the anticoagulant and anti-thrombotic activity of heparin and dermatan sulfate.

@article{Casu2004StructuralAC,
  title={Structural and conformational aspects of the anticoagulant and anti-thrombotic activity of heparin and dermatan sulfate.},
  author={Benito Casu and Marco Guerrini and Giangiacomo Torri},
  journal={Current pharmaceutical design},
  year={2004},
  volume={10 9},
  pages={
          939-49
        }
}
Heparin and other iduronic acid-containing glycosaminoglycans (GAG) such as dermatan sulfate exert their anticoagulant properties primarily by accelerating the rate of inhibition of the natural protease inhibitors antithrombin III (AT, which inhibits both factor Xa and thrombin) and heparin cofactor II (HCII, which selectively inhibits thrombin). Although AT and HCII are structural homologs, only heparin binds to AT, and HCII has different binding sites for heparin and dermatan sulfate. Whereas… CONTINUE READING

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