Structural and catalytic chemistry of magnesium-dependent enzymes

  title={Structural and catalytic chemistry of magnesium-dependent enzymes},
  author={J. Cowan},
  • J. Cowan
  • Published 2004
  • Chemistry, Medicine
  • Biometals
Magnesium dependent enzymes are ubiquitous in both general metabolic pathways and in nucleic acid biochemistry (Cowan 1995; Wilcox 1996), and their enzymatic reactions fall into one of two general classes (Figure 1). First, an enzyme may bind the magnesiumsubstrate complex. In this case the enzyme interacts principally with the substrate and shows little or at best weak interaction with Mg2+ (for example Mgisocitrate in isocitrate lyase shown in Figure 2). Alternatively, Mg2+ may bind directly… Expand
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