Structural and catalytic chemistry of magnesium-dependent enzymes

@article{Cowan2004StructuralAC,
  title={Structural and catalytic chemistry of magnesium-dependent enzymes},
  author={J. A. Cowan},
  journal={Biometals},
  year={2004},
  volume={15},
  pages={225-235}
}
  • J. A. Cowan
  • Published 2004
  • Chemistry, Medicine
  • Biometals
  • Magnesium dependent enzymes are ubiquitous in both general metabolic pathways and in nucleic acid biochemistry (Cowan 1995; Wilcox 1996), and their enzymatic reactions fall into one of two general classes (Figure 1). First, an enzyme may bind the magnesiumsubstrate complex. In this case the enzyme interacts principally with the substrate and shows little or at best weak interaction with Mg2+ (for example Mgisocitrate in isocitrate lyase shown in Figure 2). Alternatively, Mg2+ may bind directly… CONTINUE READING
    Nucleases: diversity of structure, function and mechanism.
    • 290
    Second messenger role for Mg2+ revealed by human T-cell immunodeficiency
    • 324
    Magnesium deficiency in plants: An urgent problem
    • 167
    • PDF
    Magnesium transporters: properties, regulation and structure.
    • 88
    • PDF
    The CorA family: Structure and function revisited
    • 71
    SLC41A1 Is a Novel Mammalian Mg2+ Carrier*
    • 88
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 31 REFERENCES
    A general two-metal-ion mechanism for catalytic RNA.
    • 913
    • PDF
    Recognition and cleavage of DNA by type-II restriction endonucleases.
    • 279
    Structural model for the reaction mechanism of glutamine synthetase, based on five crystal structures of enzyme-substrate complexes.
    • 110
    • Highly Influential
    Inorganic Biochemistry: An Introduction
    • 203
    • PDF
    The Biological chemistry of magnesium
    • 146
    • Highly Influential