Structural and biophysical properties of the integrin-associated cytoskeletal protein talin

@article{Roberts2009StructuralAB,
  title={Structural and biophysical properties of the integrin-associated cytoskeletal protein talin},
  author={Gordon C. K. Roberts and David R. Critchley},
  journal={Biophysical Reviews},
  year={2009},
  volume={1},
  pages={61 - 69}
}
Talin is a large cytoskeletal protein (2541 amino acid residues) which plays a key role in integrin-mediated events that are crucial for cell adhesion, migration, proliferation and survival. This review summarises recent work on the structure of talin and on some of the structurally better defined interactions with other proteins. The N-terminal talin head (approx. 50 kDa) consists of an atypical FERM domain linked to a long flexible rod (approx. 220 kDa) made up of a series of amphipathic… CONTINUE READING
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Structural determinants of integrin recognition by talin

  • B Garcia-Alvarez, JM de Pereda, +5 authors RC Liddington
  • Mol Cell 11:49–58
  • 2003
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